Influenza Research Database

Database Search

Workbench

Tools
- Retrieve a Download Retrieve a previously scheduled large data download.
- Analysis History (0) Review recently performed analyses

Submission
- Phenotype Submission Submit viral isolate information.

Data

Resources

General Information

NIAID launched this influenza virus database in 2004 to serve as a comprehensive, freely available global public database and analysis resource for the study of influenza viruses. This integrated database contains diverse data sets submitted directly from researchers, data imported from public databases, as well as information extracted from the scientific literature. Custom bioinformatics analysis tools integrated with the database are available, as well as alignment and phylogenetic analysis of genomic sequence data. Individualized work spaces are provided as well as a simplified on-line portal for submission of influenza sequences directly to GenBank. Sequences submitted to GenBank via the IRD are validated for accuracy prior to submission. NIAID is seeking feedback from the research community on improvements for the database as well as collaborators. To provide feedback please follow this link. ...

Search for segments, proteins, or strains. Filter by keyword, serotype, host, country, etc.

Segments, Proteins,
Strains

Epitopes

Surveillance

Search for strains with specified phenotypic characteristics.

Phenotype

Click to See Influenza A (H1N1) (a.k.a. Swine Flu or North American H1N1) Update

What's New

ANNOUNCEMENT

The influenza component of BioHealthBase has now been formally converted into the NIAID-sponsored Influenza Research Database. While still available from the old URL, IRD now has a new URL: www.fludb.org.

Need to know what to do about the flu? Click below.

Swine Flu Info

New Features – Release 4.11 (October 1, 2009)

The initial implementation of the IRD phylogenetic Tree Editor allows you to edit the contents of a segment working set by removing “leaves” from the phylogenetic tree created from it.
The initial implementation of the IRD Tree Decorator allows the “leaves” or “branches” of a phylogenetic tree created from a working set to be highlighted based on such characteristics as host, country, and subtype.
IRD now identifies the presence of twelve additional sequence-derived phenotype markers for such features as drug resistance, virulence, and transmissibility to humans. Sequences containing these features can be identified using the Phenotype Search.
The Surveillance data search now allows you to download all avian surveillance data or human clinical data in tab delimited format.
The Short Sequence Search now allows you to search for an amino acid sequence using any of 17 pre-computed databases consisting of all sequences of each influenza protein or of all influenza proteins.

New Resources

Google Flu Trends – Google provides statictics on internet activities releated to flu search terms by US state.

Research Using IRD

Furuse, Y. et al., Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis, Virology Journal, 2009.
zu Dohna, H. et al., Invasions by Eurasian avian influenza virus H6 genes and replacement of the its North American clade, Emerg Infect Dis, 2009.
Bose, M.E. et al., The Influenza Primer Design Resource: a new tool for translating influenza sequence data into effective diagnostics, Influenza Other Respi Viruses, 2008.
Abrahamyana, A. et al., Human H1 promoter expressed short hairpin RNAs (shRNA) suppress avian influenza replication in chicken CH-SAH and canine MDCK cells, Antiviral Research, 2009.
He, F. et al., Immunohistochemical detection of Influenza virus infection in formalin-fixed tissues with anti-H5 monoclonal antibody recognizing FFWTILKP, J Virol Methods, 2009.
Click here for a more complete list.

Upcoming Features

Sequence feature variant types for Influenza virus is coming.

Keyword Search for Influenza Segments

Team and Collaborators

You can also see Our Team and Science Advisors

IRD Mailing List

The IRD team periodically sends outs an email newsletter highlighting new features and other site functionality. Click here to sign-up for the newsletter.

Feedback

We welcome your feedback on any aspect of IRD. Suggestions of new features or how we can improve the usability of existing ones are always welcome. Click here to send us an email. We can also set up a workshop with you.

This project is funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under Contract No. HHSN266200400041C and is a collaboration between Northrop Grumman Health and Human Services, University of Texas Southwestern Medical Center, Vecna Technologies and Los Alamos National Laboratory.

Click here for details on how to cite IRD in a publication.